Cavaillon is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.

Saint Veran was bishop here in the 6th century.

The Calavon, a tributary of the Durance locally called Coulon, flows westward through the middle of the commune.

The Durance forms the commune's south-western border.

Cavaillon is famous for its melons.

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