The town of Ferrara lies on the southern shores of the Po river, about 44 km (27 mi) north-east of the regional capital, Bologna, and 87 km (54 mi) south of Venice. The territory of the municipality, entirely part of the Padan plain, is overwhelmingly flat, situated on average just 9 metres (30 ft) above sea-level. The proximity to the largest Italian river has been a constant concern in the history of Ferrara, that has been affected by recurrent, disastrous floods, the latest occurring as recently as 1951. The Idrovia Ferrarese links the river Po from Ferrara to the Adriatic at Porto Garibaldi.

The climate of the Po valley is classified as humid subtropical (Cfa) under the Köppen climate classification, a type of climate commonly referred to as "continental", that features severe winters and warm summers and heavy rains in spring and autumn.

The imposing Este Castle, sited in the very centre of the town, is iconic of Ferrara. A very large manor house featuring four massive bastions and a moat, it was erected in 1385 by architect Bartolino da Novara with the function to protect the town from external threats and to serve as a fortified residence for the Este family. It was extensively renovated in the 15th and 16th centuries.

The Cathedral of Saint George, designed by Wiligelmus and consecrated in 1135, is one of the finest examples of Romanesque architecture. The duomo has been renovated many times through the centuries, thus its resulting eclectic style is a harmonious combination of the Romanesque central structure and portal, the Gothic upper part of the façade and the Renaissance campanile. The sculptures of the main portal are attributed to Nicholaus. The upper part of the main façade, with arcades of pointed arches, dates from the 13th century. The recumbent marble lions guarding the portals are copies of the originals, now in the cathedral's museum. An elaborated 13th-century relief depicting the Last Judgement is found in the second storey of the porch. The interior was restored in baroque style in 1712. The marble campanile attributed to Leon Battista Alberti was initiated in 1412 but is still incomplete, missing one projected additional storey and a dome, as it can be observed from numerous historical prints and paintings on the subject.

Near the cathedral and the castle also lies the 15th-century city hall, that served as an earlier residence of the Este family, featuring a grandiose marble flight of stairs and two ancient bronze statues of Niccolò III and Borso of Este.

The southern district is the town's oldest, crossed by a myriad of narrow alleys that date back to the Early Middle Ages. Casa Romei is perhaps the best preserved Medieval building in Ferrara. It was the private residence of merchant Giovanni Romei, related by marriage to the Este family, and likely the work of the court architect Pietrobono Brasavola. Thanks to the nuns of the Corpus Domini order, much of the original decorations in the inner rooms have been saved. The house features fresco cycles in the "Sala delle Sibille" ("room of sibyls"), an original terracotta fireplace bearing the coat of arms of Giovanni Romei in the adjoining Saletta dei Profeti ("room of the prophets"), depicting allegories from the Bible, and in other rooms, some of which were commissioned by cardinal Ippolito d'Este, paintings by the school of Camillo and Cesare Filippi (16th century).

Palazzo Schifanoia ("sans souci") was built in 1385 for Alberto V d'Este. The palazzo includes frescoes depicting the life of Borso d'Este, the signs of the zodiac and allegorical representations of the months. The vestibule was decorated with stucco mouldings by Domenico di Paris. The building also contains fine choir-books with miniatures and a collection of coins and Renaissance medals. The Renaissance Palazzo Paradiso, part of the Ferrara University library system, displays part of the manuscript of Orlando furioso and letters by Tasso as well as Ludovico Ariosto's grave. Its famous alumni include Nicolaus Copernicus and Paracelsus.

The northern quarter, which was added by Ercole I in 1492-1505 thanks to the master plan of Biagio Rossetti, and hence called the Addizione Erculea, features a number of Renaissance palazzi. Among the finest is Palazzo dei Diamanti (Diamond Palace), named after the diamond points into which the façade's stone blocks are cut. The palazzo houses the National Picture Gallery, with a large collection of the school of Ferrara, which first rose to prominence in the latter half of the 15th century, with Cosimo Tura, Francesco Cossa and Ercole dei Roberti. Noted masters of the 16th-century School of Ferrara include Lorenzo Costa and Dosso Dossi, the most eminent of all Girolamo da Carpi and Benvenuto Tisi (il Garofalo). The district is also home to University of Ferrara Botanic Garden.