Piteå is located at the mouth of the Pite River (Swedish: Piteälven), at the shore of the Bay of Bothnia. The central part is located on an islet called Häggholmen, which due to post-glacial rebound almost has become a part of the mainland; the land in northern Sweden rises at a rate of up to 9 mm (0.35 in) per year.

Piteå's coastal location, with numerous islands and inlets, is one of the reasons it is a popular place for tourism both in summer and winter. It features a beach resort area called Pite Havsbad, around which there is a spa, a long sandy beach, a restaurant and a golf course. The area is also suitable for fishing and outdoor activities. In the winter, snow activities such as skiing and winter bathing are common. The water temperatures reportedly being Sweden's warmest during three consecutive summers in the 1950s, the beach then became known as "Norrbotten's Riviera".

Piteå is known for its pitepalt, a food dish consisting of potato dumplings with chopped pork filling. The area is also known for its dialect, called Pitemål, which however is mainly spoken by elders in surrounding villages.

Piteå has a fast food drive-thru commonly used by snowmobilers. The restaurant was a McDonald's from February 2002 to November 2007. Several McDonald's restaurants in Norrbotten closed at the time, in the face of competition from Max Hamburgers. The restaurant is now part of the Frasses hamburger chain. The drive-thru has received international coverage, including on The Travel Channel in an episode called "Most Unique McDonald's".

Piteå has a sister city in the Caribbean: Gustavia, capital of Saint Barthélemy, the formerly Swedish possession that is now part of France.