The city is located in Albania, in the District of Vlorë and County of Vlorë.

Vlorë is situated on the Bay of Vlorë, an inlet on the Adriatic Sea, almost surrounded by mountains. The port of Vlorë is closer in proximity than any other to the port of Bari, Italy, and is just 70 nautical miles (130 km) from Salento's coasts. The island of Sazan is nearby, strategically located at the entrance to the Bay of Vlorë.

The town is surrounded by gardens and olive groves. Valonia, the mass name for acorn cups obtained in the neighboring oak forests and (because of its chemical derivatives) used by tanners, derives its name from Valona, the ancient name of Vlorë.

A new motorway is being constructed linking the city with Fier and Albania as a whole. One of the most panoramic routes of the Albanian Riviera starts to the south of town stretching up to Sarandë in extreme southern Albania.