De Panne is a town and a municipality located on the North Sea coast of the Belgian province of West Flanders. There it borders France, which implies that it is the westernmost location of Belgium. It is one of the most popular resort town destinations within Belgium.

Famous people who have lived or died in De Panne include King Albert I and Queen Elisabeth, and John Aidan Liddell, VC, who died in De Panne in August 1915. The Belgian royal family lived in De Panne during the First World War because it was located in the tiny fraction of their country that was not conquered by the Germans.

De Panne is home to Plopsaland, a theme park aimed at young children and located on the former grounds of Meli Park. De Panne was also the place where the first land yachts intended for sport were built and used by the Dumont brothers in 1898.

On 17 July 1831, Leopold I, the first Belgian king, sailed to Calais from England, and arrived in Belgium in De Panne. The Leopold I Esplanade, which includes a statue of him, commemorates his arrival.

Since 1977 the town has hosted the Three Days of De Panne cycle race, which is held in the run up to, and traditionally used by riders as preparation for the Tour of Flanders.