Oswaldtwistle is a large village within the Hyndburn borough of Lancashire, England.
It lies on the course of the Leeds and Liverpool Canal, 3 miles (5 km) east-southeast of Blackburn and is contiguous with Accrington and Church.
The name is derived from "Oswald" and "Twistle". The word "twistle" is an old English word meaning "brooks meet". Legend has it that Saint Oswald, King of Northumbria passed through, giving the area its full title of Oswald's Twistle, which in time came to be Oswaldtwistle. However, it is more likely derived from the name of the Anglo-Saxon who farmed the land.
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