Saône-et-Loire is a department in the Bourgogne-Franche-Comté region in France. It is named after the rivers Saône and Loire, between which it lies, in the country's central-eastern part.

Saône-et-Loire is Bourgogne-Franche-Comté's most populous department with a population of 555,023 as of 2016. It is also its southernmost department, as it is situated on the regional border with Auvergne-Rhône-Alpes. Saône-et-Loire's prefecture is Mâcon, with subprefectures in Autun, Chalon-sur-Saône, Charolles and Louhans.

When it was formed during the French Revolution, as of March 4, 1790 in fulfillment of the law of December 22, 1789, the new department combined parts of the provinces of southern Burgundy and Bresse, uniting lands that had no previous common history nor political unity and which have no true geographical unity. Thus its history is that of Burgundy, and is especially to be found in the local histories of Autun, Mâcon, Chalon-sur-Saône, Charolles and Louhans.

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