Senigallia is a comune and port town on Italy's Adriatic coast. It is situated in the province of Ancona in the Marche region and lies approximately 30 kilometers north-west of the provincial capital city Ancona. Senigallia's small port is located at the mouth of the river Misa. It is one of the endpoints of the Massa-Senigallia Line, one of the most important dividing lines (isoglosses) in the classification of the Romance languages.

Main sights include:

• Palazzo Comunale, from the 17th century.
• Rocca Roveresca - castle of Gothic origins, restored by Baccio Pontelli in 1492. It has a square plan with four large round tower.
• The Cathedral, erected after 1787.
• Santa Maria delle Grazie - one of the only two churches attributed to Baccio Pontelli (the other is at Orciano near Mondavio, about 20 kilometres (12 miles) to the west by road).It contains a museum of the mezzadria rural life typical of the area, with work instruments, dress, photos, etc. It once housed the painting of Madonna di Senigallia by Piero della Francesca.
• Chiesa della Croce
• Rotonda a mare, an art nouveau pier