Novo Mesto is a city on a bend of the Krka River in the City Municipality of Novo Mesto in southeastern Slovenia, close to the border with Croatia. The town is traditionally considered the economic and cultural centre of the historical Lower Carniola region.

Today, tourism is increasing in Slovenia, and Novo Mesto is feeling some of the effects. The Krka Valley is becoming a place for wine enthusiasts who take tours throughout the Lower Carniola region, tasting locally produced Cvicek wine, which is produced by blending several different varieties of local wine.

Major industries include:

• Revoz (subsidiary of Renault), car manufacturing
• Adria Mobil, camper manufacturer
• Krka, pharmaceuticals