Sezana is a town in the Slovenian Littoral region of Slovenia, near the border with Italy. It is the seat of the Municipality of Sezana. Sezana is located on the Karst Plateau, 17 kilometres (11 miles) from Trieste, Italy, and 80 km (50 mi) from Ljubljana, the capital city of Slovenia.

Sights include:

• Botanical Garden
• Memorial Room commemorating the poet Srecko Kosovel
• walking trail from Sezana to Tomaj dedicated to the poet
• Karst Living museum
• Tabor nature trail