San Sebastián de La Gomera is the capital and a municipality of La Gomera in the Canary Islands, Spain. It also hosts the main harbour. The population was 8,699 in 2013, and the area is 113.59 square kilometres (43.86 sq mi).

The port serves ferry routes to the islands of Tenerife, La Palma and El Hierro. Streets include Calle Real and Fred Olsen. A bus station named Estación de Guaguas is used for bus lines throughout the island; it is located on Avenida Del Quinto Centenario.

The area was inhabited by the Guanches before the arrival of the Spanish. Hernán Peraza arrived in 1440. Christopher Columbus stopped at the harbour on 6 September 1492 before heading to India but arrived in America instead. The building in which Columbus stayed whilst on the island is now a museum.

Sites of interest include:

• Torre del Conde - a tower in the middle of the valley
• Casa del Colón, a museum dedicated to Christopher Columbus
• Museo Arqueológico de La Gomera - a museum dedicated to Guanche's social, political and religious structures
• Casa de los Peraza
• Pozo de La Aguada
• Iglesia de La Asunción and Ermita de San Sebastián Churches
• Ermita de la Virgen de Guadalupe
• Playa de San Sebastián
• Playa de la Cueva
• Mercado Municipal