Santa Cruz de la Palma (Spanish for Holy Cross of La Palma) is a city and a municipality on the east coast of the island of La Palma in the province of Santa Cruz de Tenerife of the Canary Islands. Santa Cruz de la Palma is the second-largest city (after Los Llanos de Aridane) and is the capital of the island. It is along an old lava flow coming from the Caldereta (small caldera), a volcano just south of the city.

The population of the municipality is 16,330 (2013). Around 13,000 people live within the city limits, with the remaining population residing in other settlements.

Santa Cruz de la Palma has the only major port in the island, serving ferry routes to Cádiz in Spain, as well as to Tenerife, Gran Canaria and Lanzarote. The main ferry operators in the port are Naviera Armas, Fred. Olsen Express, and Trasmediterránea. Many cruise line firms visit the port.

In Las Nieves is the Real Santuario Insular de las Virgen de las Nieves, the patron saint of the island of La Palma.