Ruse is the fifth largest city in Bulgaria. Ruse is in the northeastern part of the country, on the right bank of the Danube, opposite the Romanian city of Giurgiu, approximately 75 km (47 mi) south of Bucharest, Romania's capital, 200 km (124 mi) from the Bulgarian Black Sea Coast and 300 km (186 mi) from the capital Sofia. It is the most significant Bulgarian river port, serving an important part of the international trade of the country.

Ruse is known for its 19th- and 20th-century Neo-Baroque and Neo-Rococo architecture, which attracts many tourists. It is often called the Little Vienna. The Ruse-Giurgiu Friendship Bridge, until 14 June 2013 the only one in the shared Bulgarian-Romanian section of the Danube, crosses the river here.

Ruse is the birthplace of the Nobel laureate in Literature Elias Canetti and the writer Michael Arlen.

Ruse is on the right bank of the river Danube, which is the high bank, having two underwater terraces and three river terraces at 15 to 22 m (49.21-72.18 ft), 30 to 66 m (98.43-216.54 ft), and 54 to 65 m (177.17-213.25 ft). The average altitude is 45.5 m (149.28 ft) AMSL. The urban area is an approximately 11-km ellipse running along the river. The city extends from the land-connected Matey island and the mouth of Rusenski Lom on the west to Srabcheto hill on the east. During the 20th century, the west end of the city was significantly modified by moving the mouth of Rusenski Lom to the west, as well as by moving the bank itself with its fairway considerably to the north. Sarabair hill is to the south of the city and is 159 m (521.65 ft) high. The Rousse TV Tower is built there on the remains of Leventtabia, a former Turkish fortification.

Ruse is one of the 100 Tourist Sites of Bulgaria. The city is known for its preserved buildings from the end of the 19th and the beginning of the 20th century. There are 272 monuments of culture. Most of the sights of the city are located at the center of Ruse (museums, architectural landmarks, the theater, the opera, hotels, restaurants, cafes and souvenir shops).