Lysice is a market town in Blansko District in the South Moravian Region of the Czech Republic. It has about 1,900 inhabitants. The town is located about 12 kilometres (7 mi) northwest of Blansko and 26 km (16 mi) north of Brno. It lies on the border between the Boskovice Furrow and Upper Svratka Highlands. The highest point is at 520 m (1,710 ft) above sea level.

The first written mention of Lysice is from 1278. In 1316, it was bought by the Lords of Kunštát, who joined it to the Kunštát estate and owned the village until 1520. In 1520–1529, it was a property of the Pernštejn family. The next owners were the Cerncický of Kácov family, who founded here a pond and started construction of a water fortress. Among the most notable owners were the Breznický of Náchod family, which held it in 1584–1678. During their rule, the fortress was finished and then rebuilt into a Renaissance castle. In 1652, Lysice was promoted to a market town.