Great Shefford (or West Shefford) is an English village and civil parish on the River Lambourn in the West Berkshire district of Berkshire. The modern civil parish includes the historical parish of Little or East Shefford, a small, much-reduced community downstream. It also covers the village of Shefford Woodlands, about 1.5 miles (2.4 km) south-west of Great Shefford, near Junction 14 on the M4 motorway.

The toponym of both Sheffords is derived from the Old English for "sheep ford".