Midgham is a village and civil parish occupying slopes and the alluvial plain on the north side of the Kennet. It is centred 6 miles (10 km) east of Newbury, Berkshire and 2 miles (3.2 km) east of Thatcham. The north of the parish is 4.5 miles (7 km) south of the M4 motorway. Midgham Lock is on the Kennet and Avon canal which in summer months draws much of the water from the valley. It has smaller watercourses alongside. Its elevations range from 60 to 121 metres above sea level. Midgham Wood covers most of the north-west and Channel Wood covers most of the north-east eighth of the parish. The vast majority of the other green space is cultivated land, pasture or hay meadows. The lowland area of lakes, river and canal is greater than that covered by roads across the whole parish, as at the 2005 Office for National Statistics survey.

Midgham House or Midgham Park in the centre of the area is a building which is not listed but which has a double 15th-century red-brick former stable block with later additions and is at the top of a landscaped private park.

The Poyntz family, anciently feudal barons of Curry Mallet in Somerset, later of Iron Acton in Gloucestershire, rebuilt Midgham House and lived there 1735-1840. Residents included the diplomat Stephen Poyntz, and the MP William Stephen Poyntz. Stephen was governor to Prince William, Duke of Cumberland who spent a few years of his youth here; two rooms were added for this known as the Duke's rooms. It has a 15th-century red-brick former stable block with stone dressings which is listed in the starting category, Grade II. Neither Midgham House nor its park are listed by English Heritage under the statutory protection scheme.