Wernigerode is a town in the district of Harz, Saxony-Anhalt, Germany. Until 2007, it was the capital of the district of Wernigerode. Its population was 35,041 in 2012.

Wernigerode is located southwest of Halberstadt, and is picturesquely situated on the Holtemme river, on the north slopes of the Harz Mountains. Wernigerode is located on the German Timber-Frame Road.

The town lies at about 250 metres above sea level (NN) on the northeastern flank of the Harz Mountains in central Germany, at the foot of their highest peak, the Brocken, on the B 6 and B 244 federal highways and on the railway line from Halberstadt to Vienenburg that links the cities of Halle (Saale) and Hanover.

The River Holtemme flows through the town and, not far from its western gate, it is joined by the Zillierbach stream, which is also known as the Flutrenne near its mouth. North of the town the Barrenbach flows through several ponds and empties into the Holtemme in the village of Minsleben. The historic town centre consists of an old town and a new town (Altstadt and Neustadt). The town's borough includes Hasserode, Nöschenrode, the residential estates of Stadtfeld, Burgbreite and Harzblick as well as the villages of Benzingerode, Minsleben, Silstedt, Schierke and Reddeber.

The borough measures 9.5 km from west to east and 6 km from north to south. Its highest point is the Brocken, at 1,141 metres above NN, and its lowest is at 215 metres.

The town lies on the German-Dutch holiday road known as the Orange Route.

The Northern Harz Boundary Fault crosses the borough along which runs the watershed between the Weser and Elbe rivers. To the north precipitation flows into the Weser, to the southeast, later northeast, waters flow into the Elbe. This fault line runs through the suburb of Hasserode to the west south west of the city centre and forms the town's castle hill to the south east of the city centre.

Wernigerode contains several interesting Gothic buildings, including a fine town hall with a timber facade from 1498. Some of the quaint old houses which have escaped the numerous fires through the years are elaborately adorned with wood-carving. The Gerhart-Hauptmann Gymnasium, occupying a modern Gothic building, is the successor to an ancient grammar school that existed until 1825. The castle of the princes of Stolberg-Wernigerode rises above the town. The original was built in the 12th century but the present castle was built between 1862 and 1893 by Karl Frühling and includes parts of the medieval building.