Wittenberg is the fourth largest town in Saxony-Anhalt, Germany. Wittenberg is situated on the River Elbe, 60 kilometers (37 mi) north of Leipzig and 90 kilometers (56 mi) south-west of Berlin, and has a population of 46,008 (2018).

Wittenberg is famous for its close connection with Martin Luther and the Protestant Reformation, for which it received the honorific Lutherstadt. Several of Wittenberg's buildings associated with the events, including a preserved part of the Augustinian monastery in which Luther lived, first as a monk and later as owner with his wife Katharina von Bora and family, considered to be the world's premier museum dedicated to Luther. Wittenberg was also the seat of the Elector of Saxony, a dignity held by the dukes of Saxe-Wittenberg, making it one of the most powerful cities in the Holy Roman Empire.

Today, Wittenberg is an industrial center and popular tourist destination, best known for its intact historic center and various memorial sites dedicated to Martin Luther and Philip Melanchthon. The Luther Memorial was added to the UNESCO world heritage list in 1996.

Wittenberg is home to numerous historical sites, as well as portraits and other paintings by Lucas Cranach the Elder and Younger. On the doors of All Saints' Church, the Schlosskirche ("castle church", built in 1496-1506) Martin Luther is said to have nailed his 95 theses in 1517. It was seriously damaged by fire in 1760 during a bombardment by the French during the Seven Years' War, was practically rebuilt, and was later (1885-1892) restored. The wooden doors, burnt in 1760, were replaced in 1858 by bronze doors, bearing the Latin text of the theses. Inside the church are the tombs of Martin Luther, Philipp Melanchthon, Johannes Bugenhagen, Paul Eber and of the electors Frederick the Wise (by Peter Vischer the Younger, 1527) and John the Constant (by Hans Vischer), and portraits of the reformers by Lucas Cranach the Younger, who is also buried in the church.

St. Mary's Church, the parish church in which Luther often preached, was built in the 14th century, but has been much altered since Luther's time. It contains a painting by Lucas Cranach the Elder, representing the Last Supper (with the faces of Luther and other reformers), Baptism and Confession, also a font by Hermann Vischer the Elder (1457). In addition, there are numerous historic paintings in the church.

The ancient electoral palace is another of the buildings that suffered severely in 1760; it now contains archives.

Martin Luther's home, the Lutherhaus, where he studied and lived both before and after the Reformation, is now a museum containing many artifacts from his life. Melanchthon's house and the house of Lucas Cranach the Elder, mayor of Wittenberg, can also be found here. Statues of Luther (by Schadow), Melanchthon and Bugenhagen embellish the town. The spot outside the Elster Gate where Luther publicly burned the papal bull in 1520 is marked by an oak tree.

The original Wittenberg University quadrangle also lies in the city centre.