Neustadt an der Weinstraße is a town in Rhineland-Palatinate, Germany. With 54,000 inhabitants as of 2002, it is the largest town called Neustadt.

The town itself lies in the western park of the Rhine-Neckar Metropolitan Region between the Haardt mountains, the eastern edge of the Palatinate Forest, and the western edge of the Upper Rhine Plain in the middle of the Palatinate wine region, an area that is around 10 km wide and 85 km long. The Speyerbach river flows through the town from west to east as does the Rehbach, which separates from the Speyerbach within the town at the Winzinger Wassergescheid before emptying into the River Rhine several kilometres further north than the Speyerbach.

The borough, with its incorporated parishes, measures 22.5 km (14.0 mi) from west to east and 9.5 km (5.9 mi) from north to south. Its highest point is 619 m above sea level (NN) at the Hohe Loog House at the top of the Hohe Loog mountain and its lowest is 108 m above NN in the village of Geinsheim.

Neustadt's main attraction is its historic Altstadt or Old Town. Notable buildings include its 14th century collegiate church, the former university of Casimirianum and the Steinhauser Hof. More recently the Elwetritsche Fountain by Gernot Rumpf and the murals by Werner Holz have been added.

Outside the residential areas there are palaces and castles: Hambach Castle, the Wolfsburg, Winzingen Castle, Haardt Castle and the rather more distant Spangenberg Castle above the Elmstein Valley. In the quarter of Hambacher Höhe, by the edge of the Haardt, lies the Abbey of the Sacred Heart.

The outlying villages also have their sights; for example Mußbach with its Old Church of St. John, the manor house, White House and Carl Theodor Hof; or Gimmeldingen with St. Nicholas' Church, the Mithras Shrine, the Old Castle and King Ludwig's Pavilion.

In Neustadt, the artist, Gunter Demnig, has laid 41 so-called Stolpersteine, metal paving stones, in memory of the Jewish victims of Nazism. The first Stolperstein was laide on 6 December 2002 in front of the Kurfürst Ruprecht Gymnasium in Landwehrstraße in memory of Karl Strauß, a former teacher at the school.

On 10 March 2013 the Justice Minister for Rhineland-Palatinate, Jochen Hartloff, and Neustadt's Lord Mayor, Hans Georg Löffler, opened the memorial site to Nazi victims which had been established in the prison building of the old Turenne Barracks by a friends' association founded in 2009. Eighty years earlier, on 10 March 1933, the Nazis had established a concentration camp in the barracks for several months under the title of Schutzhaft und Arbeitslager ("Protective Detention and Labour Camp"). About 500 men from over 80 Palatine municipalities were detained here who, due to their political or religious activities, had fallen foul of the authorities.