Denham is a village and civil parish in the unitary authority of Buckinghamshire, England, approximately 17 miles (27 km) from central London, 2 miles (3 km) northwest of Uxbridge and just north of junction 1 of the M40 motorway. The name is derived from the Old English for "homestead in a valley". It was listed in the Domesday Book of 1086 as Deneham. Denham contains the Buckinghamshire Golf Club.

The Church of England parish church of Saint Mary has a flint and stone Norman tower and Tudor monuments. The tree-lined Village Road includes several old red brick houses with mature Wisteria on them, and has been used as a location in British films and television.

Southlands Manor is a Grade II listed building. Its entry on the English Heritage website states that it was built in the 16th century, with a variety of later changes including the addition of four chimney stacks in the early 17th-century. Analysis of a sample of timbers from the main building and its associated barn have found that they were felled in the winters of 1472/3 and 1473/4, indicating that the relevant parts of the building were erected in 1474 or soon after.

The Old Bakery, built in about C14, it is one of the earliest surviving buildings along the village High Street. It is located along, what would have been medieval burgage plots. The plots were for laying out a town. Built for the Abbot of Westminster, probably on instructions by Nicholas de Littlington, for his reeve. One survey suggests a very precise date of building of 1367-68, although no dendrochronology has been undertaken. The building phases and outlay are complex, with much alteration. Prior to the 1950s demolition of the former E wing the building formed three cottages/shops.

Denham Film Studios were near the village and where famous films, including Brief Encounter and In Which We Serve were produced. The buildings were demolished in 1980 and the site re-landscaped as a business park and later as a site for luxury homes.

InterContinental Hotels Group has its corporate headquarters and European head office in Denham. Bosch has its UK head office in Denham.