Acqui Terme is a city and comune in the province of Alessandria , Piedmont , northern Italy . It is about 35 kilometers (22 mi) south-southwest of Alexandria . It is one of the principal winemaking communes of the Italian DOCG wine Brachetto d'Acqui.

The hot sulfur springs have been famous since this was the Roman town of Aquae Statiellae ; the ancient baths are referred to by Paulus Diaconus and the chronicler Liutprand of Cremona. In 1870 Giovanni Ceruti designed a little pavilion, known as La Bollente , for the spot at the center of the town where the waters bubble up at 75° C (167° F).

Main sights include:

• Acqui Cathedral: Romanesque edifice on the Latin cross plan, built in the late 10th century and consecrated in 1067 to Santa Maria Assunta by bishop Guido. The façade has a portal sculpted by Antonio Pilacorte, a late 15th-century rose window and a 17th-century portico. The Gothic-style bell tower is from 1479. The interior houses a late 15th-century triptych by the Spanish artist Bartolomé Bermejo, and a Baroque altar of Saint Guido.
• The Palaeologi Castle, mentioned for the first time in 1056. It was rebuilt in the 15th century by Marquis William VII of Montferrat.
• Church of the Addolorata : also called San Pietro dates to 7th-century. It was almost entirely rebuilt in the 10th-11th centuries in Romanesque style, and attached to a Benedictine abbey. It was again renovated in the 18th century, and returned to a neo-Romanesque appearance in the 1930s.
• Church of San Francesco : rebuilt in 19th-century, stands adjacent to 15th century cloister of the former Franciscan convent.
• Church of the Madonnalta
• Sant' Antonio Abate
• Church of Madonna della Nieve
• Roman Acqueduct, also called Roman Arches Site.