Santa Margherita Ligure is a comune (municipality) in the Metropolitan City of Genoa in the Italian region Liguria , located about 35 kilometers (22 mi) southeast of Genoa , in the area traditionally known as Tigullio . It has a port, used for both tourism and fishing activities. Part of comune territory is included in the Regional Natural Park of Portofino. Santa Margherita Ligure borders the following municipalities: Camogli, Portofino, Rapallo .

Main sights include:

• Castello di Santa Margherita Ligure, built by the Republic of Genoa in 1550 as defense against the increasing attacks of North African pirates. It was designed by the same architect of the Castle of Rapallo. After World War I it was restored and entitled to the Italian victims of that conflict.
• Basilica of St. Margaret of Antiochia, built from 1658 on the remains of a 13th-century church.
• Abbazia della Cervara, a historically relevant abbey on the road to Portofino.
• Villa Durazzo complex, including two patrician villas, a 16th-century castle and 17th-century park.