Molina de Segura is a municipality of Spain in the autonomous community and province of Murcia. It is located 10 km from the provincial capital, Murcia.

It borders the towns of Las Torres de Cotillas, Alguazas, Lorquí, Ulea, Archena, Abarán, Blanca, Murcia and Fortuna. It has the fourth largest population in the region after Murcia, Cartagena and Lorca, with over 60,000 inhabitants. It is located 10 km north of the capital. The N-301 highway, that runs from Madrid to Cartagena, passes through it.

The town has a line of walls dating to the Almohad era (11th-13th centuries).

Molina de Segura is home to confectionery makers Vidal Golosinas, Jake S.A and Sánchez Cano (also known as Fini).