Aspley Guise is a village and civil parish in the west of Central Bedfordshire, England. It adjoins Woburn Sands in the Borough of Milton Keynes, Buckinghamshire. The Office for National Statistics records both as part of the Milton Keynes urban area. It is centred 6 miles (9.7 km) east southeast of Central Milton Keynes and 1 mile (1.6 km) south of the M1 junction 13. It has its own railway station, three stops from Bletchley, and an historic centre with 29 listed buildings.

Most of the cultivated land was held by the manor in the medieval period. This stayed in Acard's family until his descendant, Reginald de Ivri granted a lease to Falkes de Breauté. On confiscation of Falkes's estates in 1225 King Henry III granted the rest of the lease to Henry de Capella, however by 1227 a certain "Reginald de St. Valery" was free to release the land (entire fee) to his regent, now Henry was a 20-year-old adult, Hubert de Burgh, 1st Earl of Kent, with an official approval (confirmation of alienation).

Similarly however, in 1233 the King confiscated his lands, however Hubert was restored to all his wealth the following year in the Testa de Nevill. By 1267 it is established in the royal returns and copies (literally, rolls) of letters that he had subinfeudated the manor to Anselm de Gyse, in return for knight's service to John de Burgh and heirs.

After the middle of the 14th century the heirs of Hubert de Burgh in Aspley seem to have lapsed, and the manor was held directly of the barony of Bedford.

The tenancy was in this period that of de Guise. Anselm died in 1295 left as heir a son John, then aged 17 - his descendants inherited this tenancy and became direct tenants as mentioned. In 1428 the lord of the manor's lord briefly changed to Giles Bridges, who had married Catherine Gyse, widow, of the previous lord, Reginald Gyse, however this was brief.

Nonetheless, Catherine had from her first marriage, male issue and the House of Gyse remained with the manor's possession. As such, Sir John Gyse created a knight by Prince Arthur (Tudor), died holding Aspley Guise Manor in 1501.

In 1541, the manor of Aspley Guise was annexed to the newly formed honour of Ampthill, which in 1551 was granted for life to Princess Elizabeth (later Queen Elizabeth I).

An extent of the manor in 1560 mentions two windmills, but none survive in the historic ecclesiastical parish.

In 1560 she gave this asset by royal grant to Sir Richard Lee, military engineer. His daughter Ann, later Mrs Ralph Norwich, received permission to alienate (sell) the manor to Francis Bury, whose heir, Frances, by arrangement or fate married Ann's grandson, Thomas Lee Sadleir.

The estate passed down in a straightforward line of Sadleirs to Richard Vernon Sadleir who died in 1810, whose sister Ursula Moody inherited it. The owner in 1912 was accordingly her descendant, a certain Mr F. Moody.

The current manor house was built about 1700.

Aspley has three historic houses of higher architectural classification. Its church, equally, is Grade II* listed. The garden walls and gateway of Aspley House are listed in an entry separate from it, giving 30 structures in all identified by English Heritage as worthy of listing.

Aspley Heath is a village and civil parish, elevated and small in population and area, mostly covered by New Wavendon Heath and a smaller mixed eponymous woodland. It was until some time after 1912 part of Aspley Guise. The Office for National Statistics records the village as part of the Woburn Sands urban subdivision of the Milton Keynes urban area.