Keysoe is a village located in the Borough of Bedford in Bedfordshire, England.

Historically part of the Stodden hundred in Bedfordshire, part of Keysoe was originally located in Huntingdonshire. Today the village forms part of the Bolnhurst and Keysoe civil parish.

The Church of St Mary the Virgin is located in the village.

The College Equestrian Centre is based in Keysoe. The centre is a club and venue for horse sport events and training. The venue was used by equestrian teams training for the 2012 Summer Olympics and 2012 Summer Paralympics. 15 teams from around the world used Bedford Borough as their training base in preparation for the games.