Sharnbrook is a village and civil parish located in the Borough of Bedford in Bedfordshire, England.

The settlement was recorded in the Domesday Book of 1086 as a parish within the Hundred of Willey but was probably first developed in Saxon times. The oldest surviving building, St Peter's Church, is Norman. The name is believed to be derived from the Anglo Saxon word sharn meaning dung. Many of the older buildings in the village are constructed of the local oolitic limestone, also used in other traditional north Bedfordshire settlements.

Situated just north of a loop in the River Great Ouse and almost due north of Bedford, the village has developed as a ribbon-settlement running south-east to north-west, with the core of the community clustered at the north-western end.

A major presence is the multinational company Unilever which has the Lipton Institute of Tea research centre on the north-western edge of the village. This uses the grounds of Colworth House, originally built in the early 17th century and rebuilt in its present form by 1774 as a private house. The house itself is used as office space, with modern laboratory buildings beside and behind it. The site is being turned into a science park for use by a number of companies.