Kals am Großglockner is a municipality in the district of Lienz in the exclave of East Tirol in the Austrian state of Tyrol.

Kals is located in northern East Tirol, near the border to Salzburg and Carinthia. Located in the valleys of Kalser and Iseltals on the Kalserbach river, Kals is dominated by mountains, and the famous Großglockner mountain, the tallest mountain in all of Austria, is located partly in the municipality. Most of Kals is rugged and unusable.

The Kalser valley might have been settled before the Paleolithic Age. Kals was first mentioned on 19 August 1197. A large copper mine was begun in the 16th century here. Kals was the starting point for the first ascent of Großglockner in 1853.